Resource Library

Research & Resources

Dr. Frye’s published research, presentations, interviews, podcasts, and clinical protocols — gathered in one place. Explore by topic or type; each link opens the original source in a new tab.

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30+
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213 resources shown
News

The Phoenix Way – An interview with Richard E. Frye

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Research

Children with autism are showing ‘dramatic improvement’ with this cheap drug — and doctor behind its research says it may one day prevent the disorder

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News

Autism: Arizona doctor claims new drug is helping patients | FOX 10 Phoenix

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News

Doctor claims new drug helps treat children with autism | FOX 5 News

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Research

Parents say son with autism was nonverbal until trying an off-label drug that treats chemo side effects

cbsnews.com
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Presentation

Dr. Richard Frye on Leucovorin & Autism

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News

Parents are mistaking this supplement for a buzzy autism ‘miracle’ treatment — but doc warns it can make symptoms worse

nypost.com
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Presentation

Leucovorin For Autism: Dr. Richard Frye on New Autism and Language Research Parents Need

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Research

Transgenerational Effects and Heritability of Folate Receptor Alpha Autoantibodies in Autism Spectrum Disorder.

mdpi.com
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News

Children with autism are showing ‘dramatic improvement’ with this cheap drug — and doctor behind its research says it may one day prevent the disorder

nypost.com
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Presentation

All about Leucovorin & Benefits for the Autistic Phenotype

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Podcast

The Lisa Wexler Show – Groundbreaking Research In Autism Outcomes

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Presentation

Videos Hosted Elsewhere

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News

Taking this supplement while pregnant can make your baby smarter: study

nypost.com
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Podcast

TACA: Leucovorin and Autism

tacanowblog.com
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Podcast

Autism Parenting Secrets: Evidence-Based Treatments

autismparentingsecrets.com
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Research

Feeding-Related Early Signs of Autism Spectrum Disorder: A Narrative Review

mdpi.com
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Research

Biomarkers of mitochondrial dysfunction in autism spectrum disorder: A systematic review and meta-analysis

sciencedirect.com
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Research

Bioenergetic Signatures of Neurodevelopmental Regression

frontiersin.org
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Research

Folate Receptor Alpha Autoantibodies in the Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS) and Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections (PANDAS) Population

mdpi.com
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Research

Binding Folate Receptor Alpha Autoantibody Is a Biomarker for Leucovorin Treatment Response in Autism Spectrum Disorder

mdpi.com
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Research

Reanalysis of Trio Whole-Genome Sequencing Data Doubles the Yield in Autism Spectrum Disorder: De Novo Variants Present in Half

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Research

Preprint: High Sensitivity for Detection of Primary Diagnostic Variants in Autism, Including De Novo Variants, with Trio Whole Genome Sequencing and Data Reanalysis

autismdiscovery.org
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News

Is a Folate Deficiency Worsening Your Child’s Autism?

potomacpsychiatry.com
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News

Twenty years of autism surveillance: What are the numbers telling us?

tacanowblog.com
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Research

Synchrony 2022: Epilepsy and Seizures in Autism Spectrum Disorder Roundtable

mdpi.com
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Research

Synchrony 2022: Catalyzing Research and Treatments to Benefit Individuals with Neurodevelopmental Disorders including Autism Spectrum Disorders

mdpi.com
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Research

Biochemical, Genetic and Clinical Diagnostic Approaches to Autism-Associated Inherited Metabolic Disorders

mdpi.com
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Research

Disparities in Intellectual Disability in Autism Spectrum Disorder: A call for the immediate need for more resource

tacanowblog.com
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Patient Story

Cheston’s Story

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Patient Story

Reeve’s Story

online.flippingbook.com
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Patient Story

Meghan’s Story

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Book

A Personalized Medicine Approach to the Diagnosis and Management of Autism Spectrum Disorder

a.co
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Presentation

Levoleucovorin Treatment for Autism

youtu.be
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Presentation

Update on Mitochondrial Research in Autism

youtu.be
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Research

The Soluble Folate Receptor in Autism Spectrum Disorder: Relation to Autism Severity and Leucovorin Treatment.

mdpi.com
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Research

Long COVID Syndrome Presenting as Neuropsychiatric Exacerbations in Autism Spectrum Disorder: Insights for Treatment

mdpi.com
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Research

Air Pollution and Maximum Temperature Are Associated with Neurodevelopmental Regressive Events in Autism Spectrum Disorder

mdpi.com
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Research

Metabolomic Signatures of Autism Spectrum Disorder

mdpi.com
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Research

Blood RNA Sequencing Indicates Upregulated BATF2 and LY6E and Downregulated ISG15 and MT2A Expression in Children with Autism Spectrum Disorder

mdpi.com
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Presentation

Cerebral Folate Metabolism Presentation

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Research

Modern Biomarkers for Autism Spectrum Disorder: Future Directions

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Research

Cerebral Folate Deficiency, Folate Receptor Alpha Autoantibodies and Leucovorin (Folinic Acid) Treatment in Autism Spectrum Disorders: A Systematic Review and Meta-Analysis

mdpi.com
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Research

Central Nervous System Metabolism in Autism, Epilepsy and Developmental Delays: A Cerebrospinal Fluid Analysis

mdpi.com
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Research

Integrated microRNA–mRNA Expression Profiling Identifies Novel Targets and Networks Associated with Autism

mdpi.com
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News

Researchers connect autism symptoms with mitochondrial morphology

drugdiscoverynews.com
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Research

Time dependent changes in the bioenergetics of peripheral blood mononuclear cells: processing time, collection tubes and cryopreservation effects

ncbi.nlm.nih.gov
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Research

A Personalized Multidisciplinary Approach to Evaluating and Treating Autism Spectrum Disorder

mdpi.com
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Research

Seizures in Fragile X Syndrome: Associations and Longitudinal Analysis of a Large Clinic-Based Cohort

frontiersin.org
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Presentation

Update on Mitochondrial Research in Autism

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Research

Transdermal Electrical Neuromodulation for Anxiety and Sleep Problems in High-Functioning Autism Spectrum Disorder: Feasibility and Preliminary Findings

mdpi.com
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Research

Ratings of the Effectiveness of Nutraceuticals for Autism Spectrum Disorders: Results of a National Survey

mdpi.com
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Presentation

Neurological & Metabolic Characterization in ASD

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Research

Mitochondrial morphology is associated with respiratory chain uncoupling in autism spectrum disorder

nature.com
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Research

The Effectiveness of Cobalamin (B12) Treatment for Autism Spectrum Disorder: A Systematic Review and Meta-Analysis

mdpi.com
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Research

Resting State Functional Magnetic Resonance Imaging Elucidates Neurotransmitter Deficiency in Autism Spectrum Disorder

mdpi.com
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Research

Resting State Functional Magnetic Resonance Imaging Elucidates Neurotransmitter Deficiency in Autism Spectrum Disorder

mdpi.com
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News

Phoenix doctor’s treatment helps speech and communication for kids with autism

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Research

MicroRNA Expression Profiles in Autism Spectrum Disorder: Role for miR-181 in Immunomodulation

mdpi.com
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Research

Locked-in Intact Functional Networks in Children with Autism Spectrum Disorder: A Case-Control Study

mdpi.com
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Research

A Systematic Review and Meta-Analysis of Immunoglobulin G Abnormalities and the Therapeutic Use of Intravenous Immunoglobulins (IVIG) in Autism Spectrum Disorder

mdpi.com
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Research

Physiological mediators of prenatal environmental influences in autism spectrum disorder

onlinelibrary.wiley.com
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Research

Mitochondrial Fatty Acid β-Oxidation and Resveratrol Effect in Fibroblasts from Patients with Autism Spectrum Disorder

mdpi.com
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Research

Emerging biomarkers in autism spectrum disorder: a systematic review

atm.amegroups.com
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Research

Randomized controlled trial of sulforaphane and metabolite discovery in children with Autism Spectrum Disorder

pubmed.ncbi.nlm.nih.gov
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Presentation

Live interview with Dr. Richard Frye

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Research

Mitochondria May Mediate Prenatal Environmental Influences in Autism Spectrum Disorder

mdpi.com
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Presentation

Autism Research Presentation

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Research

Treatment of Folate Metabolism Abnormalities in Autism Spectrum Disorder

sciencedirect.com
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Research

Prenatal air pollution influences neurodevelopment and behavior in autism spectrum disorder by modulating mitochondrial physiology

nature.com
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Research

Early life metal exposure dysregulates cellular bioenergetics in children with regressive autism spectrum disorder

nature.com
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Research

Mitochondrial Dysfunction in Autism Spectrum Disorder: Unique Abnormalities and Targeted Treatments

sciencedirect.com
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Presentation

Autism & Seizures

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Research

Developmental regression and mitochondrial function in children with autism

onlinelibrary.wiley.com
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Presentation

Seizures and Epilepsy in Autism Spectrum Disorder

youtube.com
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Research

Evaluation of the Cunningham Panel™ in pediatric autoimmune neuropsychiatric disorder associated with streptococcal infection (PANDAS) and pediatric acute-onset neuropsychiatric syndrome (PANS): Changes in antineuronal antibody titers parallel changes in patient symptoms

linkinghub.elsevier.com
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Research

Peripheral Blood Mononuclear Cell Oxytocin and Vasopressin Receptor Expression Positively Correlates with Social and Behavioral Function in Children with Autism

nature.com
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Podcast

New program trains more Valley doctors to diagnose autism

ktar.com
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Research

Inheritance of HLA-Cw7 Associated With Autism Spectrum Disorder (ASD)

frontiersin.org
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Research

Association With Monocyte Cytokine Profiles and Mitochondrial Respiration

ncbi.nlm.nih.gov
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Research

Serum microRNAs in ASD: Association With Monocyte Cytokine Profiles and Mitochondrial Respiration

frontiersin.org
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Presentation

Figuring Out the Biological Mechanism Behind PANS/PANDAS

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Presentation

PANS and Autism

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Research

A comparative study of mitochondrial respiration in circulating blood cells and skeletal muscle fibers in women

journals.physiology.org
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Research

Mitochondrial Dysfunction Is Inducible in Lymphoblastoid Cell Lines From Children With Autism and May Involve the TORC1 Pathway

frontiersin.org
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Presentation

Autism & Folate Presentation

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Research

Nuclear Peroxisome Proliferator-Activated Receptors (PPARs) as Therapeutic Targets of Resveratrol for Autism Spectrum Disorder

mdpi.com
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Research

Reliability of the Cunningham Panel

nature.com
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Research

Rating of the Effectiveness of 26 Psychiatric and Seizure Medications for Autism Spectrum Disorder: Results of a National Survey

ncbi.nlm.nih.gov
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Research

Variations in Mitochondrial Respiration Differ in IL-1ß/IL-10 Ratio Based Subgroups in Autism Spectrum Disorders

frontiersin.org
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Book

The Therapeutic Use of N-Acetylcysteine (NAC) in Medicine

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News

Barrow Neurological Institute at Phoenix Children’s is at the Forefront of Autism Research with Two New Grants

phoenixchildrens.org
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Research

A Subset of Patients With Autism Spectrum Disorders Show a Distinctive Metabolic Profile by Dried Blood Spot Analyses.

frontiersin.org
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Research

Clinical and Molecular Characteristics of Mitochondrial Dysfunction in Autism Spectrum Disorder

link.springer.com
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News

Can Immunotherapy Treat Autism?

jwatch.org
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Research

Intravenous immunoglobulin for the treatment of autoimmune encephalopathy in children with autism

nature.com
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Research

Social Skills Deficits in Autism Spectrum Disorder: Potential Biological Origins and Progress in Developing Therapeutic Agents

link.springer.com
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News

Success of blood test for autism affirmed

sciencedaily.com
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Research

Multivariate techniques enable a biochemical classification of children with autism spectrum disorder versus typically-developing peers: A comparison and validation study

aiche.onlinelibrary.wiley.com
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Presentation

How to increase your chances of a healthy pregnancy and a healthy child

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Slides

The Association of Autism and Down Syndrome – Slides

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Research

Comparison of Treatment for Metabolic Disorders Associated with Autism:Reanalysis of Three Clinical Trials

frontiersin.org
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Research

Butyrate enhances mitochondrial function during oxidative stress in cell lines from boys with autism

nature.com
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Research

Folinic acid improves verbal communication in children with autism and language impairment: a randomized double-blind placebo-controlled trial

nature.com
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Research

Treatment with folate in autism spectrum disorder Folinic acid improves verbal communication in children with autism and language impairment: a randomized double-blind placebo-controlled trial.

nature.com
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Research

Modulation of Immunological Pathways in Autistic and Neurotypical Lymphoblastoid Cell Lines by the Enteric Microbiome Metabolite Propionic Acid

nature.com
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Research

Patient care standards for primary mitochondrial disease: a consensus statement from the Mitochondrial Medicine Society

linkinghub.elsevier.com
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Slides

Seizures and Epilepsy in Autism Spectrum Disorder – Slides

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Research

Novel biomarkers of metabolic dysfunction is autism spectrum disorder: potential for biological diagnostic markers

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Research

Folate metabolism abnormalities in autism: potential biomarkers

futuremedicine.com
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News

Health Matters: Shedding Light on PANS and PANDAS

kark.com
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Presentation

Folate Metabolism, Mitochondrial Disease and ASD

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Research

Oxidative Stress Challenge Uncovers Trichloroacetaldehyde Hydrate-Induced Mitoplasticity in Autistic and Control Lymphoblastoid Cell Lines.

nature.com
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Research

Autistic Siblings with Novel Mutations in Two Different Genes: Insight for Genetic Workups of Autistic Siblings and Connection to Mitochondrial Dysfunction.

frontiersin.org
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Research

The Effect of Mitochondrial Supplements on Mitochondrial Activity in Children with Autism Spectrum Disorder.

mdpi.com
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Research

Bioenergetic variation is related to autism symptomatology.

link.springer.com
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Research

Mitochondrial dysfunction in the gastrointestinal mucosa of children with autism: A blinded case-control study.

journals.plos.org
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Research

Thyroid dysfunction in children withautism spectrum disorder is associated with folate receptor α autoimmune disorder.

onlinelibrary.wiley.com
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Research

Mitochondrial and redox abnormalities in autism lymphoblastoid cells: a sibling control study

faseb.onlinelibrary.wiley.com
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News

Folinic Acid May Improve Verbal Skills in Children With ASD

psychnews.psychiatryonline.org
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Podcast

Research Shows Folinic Acid Could Help Autistic Children Communicate Better

kuaf.com
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Research

Modulation of mitochondrial function by the microbiome metabolite propionic acid in autism and control cell lines

nature.com
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News

Small study finds folinic acid improves communication & eases symptoms of autism

autismspeaks.org
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News

Folinic acid could help children with autism communicate better

upi.com
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News

Folinic acid could help children with autism communicate better

medicalxpress.com
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News

Folinic acid could help children with autism communicate better

eurekalert.org
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Research

The Significance of the Enteric Microbiome on the Development of Childhood Disease: A Review of Prebiotic and Probiotic Therapies in Disorders of Childhood.

journals.sagepub.com
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News

The Families That Launch Their Own Autism Studies

theatlantic.com
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Presentation

Dr. Frye Discusses Autism Spectrum Disorders, PANDAS and PANS

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Research

Primary Mitochondrial Disease and Secondary Mitochondrial Dysfunction: Importance of Distinction for Diagnosis and Treatment

karger.com
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Research

Identification and Treatment of Pathophysiological Comorbidities of Autism Spectrum Disorder to Achieve Optimal Outcomes

journals.sagepub.com
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Research

Neuropathological Mechanisms of Seizures in Autism Spectrum Disorder

ncbi.nlm.nih.gov
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Podcast

Autism Research Connections #1

soundcloud.com
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Research

Mitochondrial Dysfunction may explain symptom variation in Phelan-McDermid Syndrome.

nature.com
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Research

Blocking and Binding Folate Receptor Alpha Autoantibodies Identify Novel Autism Spectrum Disorder Subgroups

frontiersin.org
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Research

Environmental Toxicants and Autism Spectrum Disorder

psychiatrictimes.com
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News

N of One: Autism Research Foundation Interviews Richard Frye, MD PhD on Folinic Acid & Autism Trial

nofone.org
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Research

Enteric Ecosystem Disruption in Autism Spectrum Disorder: Can the Microbiota and Macrobiota be Restored?

eurekaselect.com
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News

Richard E Frye, MD, PhD. is “All In” for Autistic Children

issuu.com
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Research

Treatment for Sleep Problems in Children with Autism and Caregiver Spillover Effects

link.springer.com
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Research

Entorhinal Cortex Thickness across the Human Lifespan

onlinelibrary.wiley.com
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Presentation

Prevention is Possible

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Presentation

Cellular Research in Autism

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Presentation

The Healthy Child Guide

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Podcast

Autism and Care

think.kera.org
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Podcast

Understanding Autism: A Father’s Search Beyond Genetics

keranews.org
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Research

Approaches to studying and manipulating the enteric microbiome to improve autism symptoms

europepmc.org
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News

Pieces of the puzzle

issuu.com
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Research

Sudden Onset Complex Tic Associated with Streptococcal Infection in a Neonate: The First Case of Neonatal PANDAS

najms.com
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Research

Metabolic and mitochondrial disorders associated with epilepsy in children with autism spectrum disorder.

pubmed.ncbi.nlm.nih.gov
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Research

Gastrointestinal dysfunction in autism spectrum disorder: the role of the mitochondria and the enteric microbiome.

tandfonline.com
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Research

Supplement 1, 2015: The Microbiome in Autism Spectrum Disorder

tandfonline.com
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Research

Treatments for biomedical abnormalities associated with autism spectrum disorder

frontiersin.org
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Podcast

Autism, Mito and Oxidative Stress

episodes.castos.com
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Research

Clinical potential, safety, and tolerability of arbaclofen in the treatment of autism spectrum disorder

dovepress.com
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Research

Environmental toxicants and autism spectrum disorders: a systematic review.

nature.com
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Research

Oxidative stress induces mitochondrial dysfunction in a subset of autism lymphoblastoid cell lines in a well-matched case control cohort.

journals.plos.org
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Research

Oxidative stress induces mitochondrial dysfunction in a subset of autistic lymphoblastoid cell lines.

nature.com
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Research

Evidence linking oxidative stress, mitochondrial dysfunction, and inflammation in the brain of individuals with autism.

frontiersin.org
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Research

Effectiveness of methylcobalamin and folinic Acid treatment on adaptive behavior in children with autistic disorder is related to glutathione redox status

hindawi.com
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Research

A review of traditional and novel treatments for seizures in autism spectrum disorder: findings from a systematic review and expert panel

frontiersin.org
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Research

A lack of statistical pitfalls in the comparison of multivariate causality measures for effective causality

sciencedirect.com
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Research

Tract-based spatial statistics reveal altered relationship between non-verbal reasoning abilities and white matter integrity in autism spectrum disorder

cambridge.org
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Research

Metabolic effects of sapropterin treatment in autism spectrum disorder: a preliminary study

nature.com
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Research

Unique acyl-carnitine profiles are potential biomarkers for acquired mitochondrial disease in autism spectrum disorder.

nature.com
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Research

Redox Metabolism Abnormalities in Autistic Children Associated with Mitochondrial Disease

nature.com
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Research

Synchronization between the anterior and posterior cortex determines consciousness level in patients with traumatic brain injury (TBI)

sciencedirect.com
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Research

Network‐based analysis reveals stronger local diffusion‐based connectivity and different correlations with oral language skills in brains of children with high functioning autism spectrum disorders

onlinelibrary.wiley.com
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Research

Laterality of temporoparietal causal connectivity during the prestimulus period correlates with phonological decoding task performance in dyslexic and typical readers

academic.oup.com
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Research

Global cerebral and regional multimodal neuroimaging markers of the neurobiology of autism: development and cognition

journals.sagepub.com
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Podcast

Mito, Autism and Cerebral Folate Deficiency

podbay.fm
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Research

Mitochondrial disease in 22q13 duplication syndrome.

journals.sagepub.com
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Research

Substantial problems with measuring brain mitochondrial dysfunction in autism spectrum disorder using magnetic resonance spectroscopy.

link.springer.com
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Research

A review of research trends in physiological abnormalities in autism spectrum disorders: immune dysregulation, inflammation, oxidative stress, mitochondrial dysfunction and environmental toxicant exposures.

nature.com
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Research

Mitochondrial Dysfunction in Autism Spectrum Disorders: A Systematic Review and Meta-Analysis.

nature.com
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Research

Cerebral folate receptor autoantibodies in autism spectrum disorder.

nature.com
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Research

Evidence of oxidative damage and inflammation associated with low glutathione redox status in the autism brain.

nature.com
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News

Dr. Richard Frye Interview

cogentbenger.com
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Research

Cerebral folate receptor autoantibodies in autism spectrum disorder

nature.com
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Research

Multichannel least-squares linear regression provides a fast, accurate, unbiased and robust estimation of Granger causality for neurophysiological data

sciencedirect.com
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Research

Melatonin in autism spectrum disorders: a systematic review and meta-analysis

onlinelibrary.wiley.com
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Research

Diffusion tensor quantification of the relations between microstructural and macrostructural indices of white matter and reading

onlinelibrary.wiley.com
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Research

A comparison of multivariate causality based measures of effective connectivity

sciencedirect.com
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Research

Traditional and non-traditional treatments for autism spectrum disorder with seizures: an on-line survey

bmcpediatr.biomedcentral.com
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Research

A review of research trends in physiological abnormalities in autism spectrum disorders: immune dysregulation, inflammation, oxidative stress, mitochondrial dysfunction and environmental toxicant exposures

nature.com
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Research

Mitochondrial dysfunction can connect the diverse medical symptoms associated with autism spectrum disorders.

nature.com
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Research

Diffusion tensor‐based regional gray matter tissue segmentation using the international consortium for brain mapping atlases

onlinelibrary.wiley.com
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Research

Greater Pre-Stimulus Effective Connectivity from the Left Inferior Frontal Area to other Areas is Associated with Better Phonological Decoding in Dyslexic Readers

frontiersin.org
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Research

Diffusion tensor tractography of the human brain cortico-ponto-cerebellar pathways: a quantitative preliminary study

onlinelibrary.wiley.com
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Research

Human brain atlas-based volumetry and relaxometry: application to healthy development and natural aging

onlinelibrary.wiley.com
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Research

Preterm birth and maternal responsiveness during childhood are associated with brain morphology in adolescence

cambridge.org
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Research

Superior longitudinal fasciculus and cognitive dysfunction in adolescents born preterm and at term

onlinelibrary.wiley.com
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Research

Tetrahydrobiopterin as a novel therapeutic intervention for autism

link.springer.com
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Research

Increased left prefrontal activation during an auditory language task in adolescents born preterm at high risk

sciencedirect.com
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Research

Information communication networks in severe traumatic brain injury

link.springer.com
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Research

Electroencephalogram discharges in atypical cognitive development

ncbi.nlm.nih.gov
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Research

Surface Area Accounts for the Relation of Gray Matter Volume to Reading-Related Skills and History of Dyslexia

academic.oup.com
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Protocol

Propranolol

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Protocol

Folinic Acid (Leucovorin Calcium)

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Autoimmune Brain Panel

moleculera.com
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Mitochondrial Cheek Swab Test (MITOSWAB)

religendx.com
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Folate Receptor Alpha Autoantibody Test (FRAT)

fratnow.com
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Research

Increased prefrontal activation in adolescents born prematurely at high risk during a reading task

sciencedirect.com
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Research

Reversible posterior leukoencephalopathy syndrome in sickle-cell anemia

linkinghub.elsevier.com
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Research

Functional Neuroimaging of Language Using Magnetoencephalography

sciencedirect.com
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Research

Receptive language organization in high-functioning autism

journals.sagepub.com
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Book

Future Application of Clinical MEG

amazon.com
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Research

Splenium microstructure is related to two dimensions of reading skill

journals.lww.com
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Research

Touch, sound and vision in human superior temporal sulcus

sciencedirect.com
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Research

Objective Phonological and Subjective Perceptual Characteristics of Syllables Modulate Spatiotemporal Patterns of Superior Temporal Gyrus Activity

ncbi.nlm.nih.gov
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Research

Linear coding of voice onset time

direct.mit.edu
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Research

Choroid plexus papilloma expansion over 7 years in Aicardi syndrome

journals.sagepub.com
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Research

Developmental regression and mitochondrial dysfunction in a child with autism.

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