Research Topic

Cerebral Folate Deficiency

Folate receptor α autoantibodies disrupt folate transport across the blood-brain barrier — a treatable ASD subgroup that often responds to folinic acid.

Cerebral Folate Deficiency

Transgenerational Effects and Heritability of Folate Receptor Alpha Autoantibodies in Autism Spectrum Disorder.

TACA: Leucovorin and Autism

Folate Receptor Alpha Autoantibodies in the Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS) and Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections (PANDAS) Population

Binding Folate Receptor Alpha Autoantibody Is a Biomarker for Leucovorin Treatment Response in Autism Spectrum Disorder

Is a Folate Deficiency Worsening Your Child’s Autism?

Reeve’s Story

Levoleucovorin Treatment for Autism

The Soluble Folate Receptor in Autism Spectrum Disorder: Relation to Autism Severity and Leucovorin Treatment.

Cerebral Folate Metabolism Presentation

Cerebral Folate Deficiency, Folate Receptor Alpha Autoantibodies and Leucovorin (Folinic Acid) Treatment in Autism Spectrum Disorders: A Systematic Review and Meta-Analysis

Phoenix doctor’s treatment helps speech and communication for kids with autism

Live interview with Dr. Richard Frye

Treatment of Folate Metabolism Abnormalities in Autism Spectrum Disorder

Autism & Folate Presentation

Treatment with folate in autism spectrum disorder Folinic acid improves verbal communication in children with autism and language impairment: a randomized double-blind placebo-controlled trial.

Folate metabolism abnormalities in autism: potential biomarkers

Folate Metabolism, Mitochondrial Disease and ASD

Thyroid dysfunction in children withautism spectrum disorder is associated with folate receptor α autoimmune disorder.

Folinic Acid May Improve Verbal Skills in Children With ASD

Research Shows Folinic Acid Could Help Autistic Children Communicate Better

Small study finds folinic acid improves communication & eases symptoms of autism

Folinic acid could help children with autism communicate better

Folinic acid could help children with autism communicate better

Folinic acid could help children with autism communicate better

The Families That Launch Their Own Autism Studies

Autism Research Connections #1

Blocking and Binding Folate Receptor Alpha Autoantibodies Identify Novel Autism Spectrum Disorder Subgroups

N of One: Autism Research Foundation Interviews Richard Frye, MD PhD on Folinic Acid & Autism Trial

Richard E Frye, MD, PhD. is “All In” for Autistic Children

Mito, Autism and Cerebral Folate Deficiency

Cerebral folate receptor autoantibodies in autism spectrum disorder.

Folinic Acid (Leucovorin Calcium)

Folate Receptor Alpha Autoantibody Test (FRAT)

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