Precision Care for Children with Autism & Neurodevelopmental Disorders
Dr. Richard E. Frye, MD, PhD — Behavioral Child Neurologist, Researcher, and Author
Now Available
The Folate Fix
Dr. Frye’s new book explores the role of folate in autism and neurodevelopmental disorders — and how cerebral folate deficiency, an often-overlooked syndrome treatable with leucovorin, offers new hope for thousands of families.
Who Are You?
Find the resources most relevant to you.
Parents & Caregivers
Trusted information about your child’s condition, treatment options, and the latest research — written in plain language.
Clinicians & Researchers
217+ peer-reviewed publications organized by topic. Browse research by mechanism, treatment, or clinical protocol.
Patients & Future Patients
Request an appointment, learn what to expect during your first visit, and access patient resources.
As recently featured on CBS Evening News — covering breakthroughs in cerebral folate deficiency and autism treatment.
Latest Research
Recent publications and interviews from Dr. Frye and his research collaborators.
- Children with autism are showing ‘dramatic improvement’ with this cheap drug — and doctor behind its research says it may one day prevent the disorderBy McKenzie Beard Published March 19, 2025, 6:00 a.m. ET
- Parents say son with autism was nonverbal until trying an off-label drug that treats chemo side effectsBy Dr. Céline Gounder
- Transgenerational Effects and Heritability of Folate Receptor Alpha Autoantibodies in Autism Spectrum Disorder.Frye, R.E.; Cohen, I.L.; Sequeira, J.M.; Hill, Z.; Espinoza, A.; Brown, W.T.; Mevs, C.; Marchi, E.; Flory, M.; Jenkins, E.C.; et al. Transgenerational Effects… Read more: Transgenerational Effects and Heritability of Folate Receptor Alpha Autoantibodies in Autism Spectrum Disorder.
- Feeding-Related Early Signs of Autism Spectrum Disorder: A Narrative ReviewCastro K, Frye RE, Silva E, Vasconcelos C, Hoffmann L, Riesgo R, Vaz J. 3 2024. Journal of Personalized Medicine.; 14(8):823. Read Article
Our Mission
To advance the understanding and treatment of autism and neurodevelopmental disorders through precision personalized care, rigorous research, and compassionate clinical practice — empowering families with evidence-based hope.