Dr. Richard E. Frye, MD, PhD
Behavioral Child Neurologist, Researcher, and Author
Dr. Richard Frye is a Child Neurologist with expertise in neurodevelopmental and neurometabolic disorders. He received an MD and PhD in Physiology and Biophysics from Georgetown University, completed a residency in Pediatrics at the University of Miami, a residency in Child Neurology and fellowship in Behavioral Neurology and Learning Disabilities at Harvard University / Children’s Hospital Boston, and a fellowship in Psychology at Boston University. He also holds a Master’s in Biomedical Science and Biostatistics from Drexel University, with board certifications in Pediatrics and in Neurology with Special Competence in Child Neurology.
A national leader in autism research, Dr. Frye has authored over 300 peer-reviewed publications and book chapters and serves on several editorial boards. He has led clinical studies on children with autism spectrum disorder (ASD), defining the clinical, behavioral, cognitive, genetic, and metabolic characteristics of children with ASD and mitochondrial disease, and conducted several clinical trials demonstrating the efficacy of safe and novel treatments that target underlying physiological abnormalities — including open-label studies on tetrahydrobiopterin, cobalamin, and folinic acid, and a recent double-blind placebo-controlled trial on folinic acid. His ongoing research focuses on defining metabolic endophenotypes of children with ASD and developing targeted treatments.
He currently sees American patients at Rossignol Medical Center and international patients at Neurodevelopmental Precision Medicine. In 2022 he co-founded The Autism Discovery and Treatment Foundation, a 501(c)(3) non-profit dedicated to researching biomarkers and treatments for complicated neurodevelopmental disorders.
I want to offer hope to families raising children who have challenging neurodevelopmental disorders. I believe there is so much more we could do to improve the lives of children with autism and their families. We have hope that one day, in the not-so-distant future, our dedication to research will lead to discovery of the causes of autism, better ways to treat children with autism, and eventually ways to prevent autism.
Dr. Richard E. Frye