Behavioral Child Neurologist · Researcher · Author
Precision care for children with autism and neurodevelopmental disorders.
Dr. Richard E. Frye has spent three decades advancing the science behind autism — from cerebral folate deficiency to mitochondrial dysfunction — and translating that research into personalized care for families.
As recently featured on CBS Evening News — Dr. Frye was interviewed about his research treating children with autism using leucovorin.
About Dr. Frye
A career dedicated to understanding neurodevelopmental disorders
As a child neurologist, Dr. Frye recognized a general lack of understanding regarding the causes and treatments of neurodevelopmental disabilities. He pursued specialized fellowships in Behavioral Neurology and Learning Disabilities, and in Psychology.
“I found that there were many causes of neurodevelopmental disabilities. Amazingly, some children actually started to improve with simple, safe medical treatments.”
His clinical practice, research, and education are all aimed at systematically diagnosing and treating the underlying causes of disability in children with neurodevelopmental disorders, including autism spectrum disorder.
New Release
New Book
The Folate Fix
Exploring the Role of Folate in Autism and Neurodevelopmental Disorders
This book explores cerebral folate deficiency (CFD) — a serious yet often overlooked syndrome linked to autism spectrum disorder. It features stories from parents who have witnessed remarkable improvements, and provides clinicians with essential evaluation strategies and treatment best practices.
Who This Site Serves
Resources for every stage of the journey
Whether you’re a parent seeking answers, a clinician exploring research, or a family looking for personalized care.
Parents & Caregivers
Guides, presentations, and research summaries — written for the advocates who know their children best and fight the hardest.
Clinicians & Researchers
Published research organized by topic — from cerebral folate deficiency to mitochondrial dysfunction — with collaborative work from across the field.
Patients & Families
Information about booking appointments at U.S. and European clinics, plus peer-to-peer consultation services for physicians and providers.
Latest Research